Bifunctional Metal-Organic Framework Synergistically Enhances
Radiotherapy and Activates STING for Potent Cancer Radio-
Immunotherapy
Chaoyu Wang#, Jinhong Li# , Xiaomin Jiang#, Xin Ma, Wenyao Zhen, Langston Tillman, Ralph R. Weichselbaum*, Wenbin Lin*Angew. Chem. Int. Ed. 2024, e202417027 STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition
Xiaomin Jiang, Taokun Luo, Kaiting Yang, Morten J Lee, Jing Liu, Langston Tillman, Wenyao Zhen, Ralph R Weichselbaum, Wenbin Lin* (highlighted by UChicago news & UChicago BSD news!)Sci. Adv. 10 (29), eado0082 Nanoscale Metal‐Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity
Gan Lin, Langston Tillman, Taokun Luo, Xiaomin Jiang, Yingjie Fan, Gang Liu, Wenbin Lin*Angew. Chem. Int. Ed. 2024, e202410241. STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses
Taokun Luo#, Xiaomin Jiang#, Yingjie Fan, Eric Yuan, Jinhong Li, Langston Tillman, Wenbin Lin*Natl. Sci. Rev. 2024, 10, nwae167. Phosphate Coordination to Metal-Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy
Taokun Luo#, Xiaomin Jiang#, Jinhong Li#, Geoffrey T Nash, Eric Yuan, Luciana Albano, Langston Tillman, Wenbin Lin*Angew. Chem. Int. Ed. 2024, 63, e202319981. Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy
Jing Liu#, Xiaomin Jiang#, Youyou Li, Kaiting Yang, Ralph R Weichselbaum*, Wenbin Lin*ACS Nano 2024, 18, 6, 5152–5166. Nanoscale covalent organic framework with staggered stacking of phthalocyanines for mitochondria-targeted photodynamic therapy
Jing Liu, Dong Won Kang, Yingjie Fan, Geoffrey T Nash, Xiaomin Jiang, Ralph R Weichselbaum, Wenbin Lin*J. Am. Chem. Soc. 2024, 146, 1, 849–857. Mechanoregulatory Cholesterol Oxidase‐Functionalized Nanoscale Metal–Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells
Wenyao Zhen, Taokun Luo, Zitong Wang, Xiaomin Jiang, Eric Yuan, Ralph R Weichselbaum, Wenbin Lin*Small 2023, 2305440. Nanoscale Coordination Polymer Synergizes Photodynamic Therapy and Toll-Like Receptor Activation for Enhanced Antigen Presentation and Antitumor Immunity
Xiaomin Jiang, Jing Liu, Morten J. Lee, Cheng Peng, Taokun Luo, Langston Tillman, Ralph R. Weichselbaum, Wenbin Lin*Biomaterials 2023, 302, 122334. Co-delivery of Three Synergistic Chemotherapeutics in A Core-Shell Nanoscale Coordination Polymer for the Treatment of Pancreatic Cancer
Xiaomin Jiang, Morten J. Lee, Taokun Luo, Langston Tillman, Wenbin Lin*Biomaterials 2023, 301, 122235. Nanoscale Metal–Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy
Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R Weichselbaum, Wenbin Lin*J. Am. Chem. Soc. 2023, 145, 18698-18704. Metal‐Organic Layer Delivers 5‐Aminolevulinic Acid and Porphyrin for Dual‐Organelle‐Targeted Photodynamic Therapy
Taokun Luo, Yingjie Fan, Jianming Mao, Xiaomin Jiang, Luciana Albano, Eric Yuan, Tomas Germanas, Wenbin Lin*Angew. Chem. Int. Ed. 2023, 62, e202301910. Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis
Xiaomin Jiang, Jianqiao Liu, Jianming Mao, Wenbo Han, Yingjie Fan, Taokun Luo, Junjie Xia, Morten J Lee, Wenbin Lin*Biomaterials 2023, 295, 122037. A Three-in-One Nanoscale Coordination Polymer for Potent Chemo-Immunotherapy
Jing Liu#, Xiaomin Jiang#, Xuanyu Feng, Morten J Lee, Youyou Li, Jianming Mao, Ralph R Weichselbaum, Wenbin Lin*Small Method. 2023, 2201437. Two-stage SN38 release from a core–shell nanoparticle enhances tumor deposition and antitumor efficacy for synergistic combination with immune checkpoint blockade
Xiaomin Jiang, Morten Lee, Junjie Xia, Taokun Luo, Jianqiao Liu, Megan Rodriguez, Wenbin Lin*ACS Nano 2022, 16, 21417–21430 Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration
Kaiting Yang#, Wenbo Han#, Xiaomin Jiang#, Andras Piffko, Jason Bugno, Chuanhui Han, Sirui Li, Hua Liang, Ziwan Xu, Wenxin Zheng, Liangliang Wang, Jiaai Wang, Xiaona Huang, Jenny PY Ting, Yang-Xin Fu, Wenbin Lin*, Ralph R Weichselbaum*Nat. Nanotech. 2022, 17, 1322-1331. TLR3 agonist nanoscale coordination polymer synergizes with immune checkpoint blockade for immunotherapy of cancer
Yingying Li#, Xiaomin Jiang#, Taokun Luo, Junjie Xia, Morten J Lee, Ralph R Weichselbaum*, Wenbin Lin*Biomaterials 2022, 290, 121831. A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy
Taokun Luo, Geoffrey T Nash, Xiaomin Jiang, Xuanyu Feng, Jianming Mao, Jianqiao Liu, Aditya Juloori, Alexander T Pearson, Wenbin Lin*Adv. Mater. 2022, 34, 2110588. Tumor‐Activatable Nanoparticles Target Low‐Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy
Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R Weichselbaum, Wenbin Lin*Adv. Sci. 2022, 2201614. Nanoscale coordination polymers for combined chemotherapy and photodynamic therapy of metastatic cancer
Youyou Li, Wenbo Han, Chunbai He, Xiaomin Jiang, Yingjie Fan, Wenbin Lin*Bioconjugate Chem. 2021, 32, 2318-2326. Nanoscale metal–organic framework confines zinc-phthalocyanine photosensitizers for enhanced photodynamic therapy
Taokun Luo, Geoffrey T Nash, Ziwan Xu, Xiaomin Jiang, Jianqiao Liu, Wenbin Lin*J. Am. Chem. Soc. 2021, 143, 34, 13519–13524. Supramolecular metal-based nanoparticles for drug delivery and cancer therapy
Xiaomin Jiang, Chunbai He, Wenbin Lin*Curr. Opin. in Chem. Biol., 2021, 61, 143-153. Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy
Xiang Ling#, Wenbo Han#, Xiaomin Jiang#, Xing Chen, Megan Rodriguez, Pingping Zhu, Tong Wu, Wenbin Lin*Biomaterials 2021, 270, 120690. Sequential treatment of bioresponsive nanoparticles elicits antiangiogenesis and apoptosis and synergizes with a CD40 agonist for antitumor immunity
Xiang Ling, Xiaomin Jiang, Youyou Li, Wenbo Han, Megan Rodriguez, Ziwan Xu, Wenbin Lin*ACS Nano 2021, 15, 765-780. Nanoscale metal–organic frameworks stabilize bacteriochlorins for type I and type II photodynamic therapy
Taokun Luo, Kaiyuan Ni, August Culbert, Guangxu Lan, Zhe Li, Xiaomin Jiang, Michael Kaufmann, Wenbin Lin*J. Am. Chem. Soc. 2021, 143, 34, 13519–13524. The cytochrome c–cyclo [6] aramide complex as a supramolecular catalyst in methanol
Wang Pan, Lijun Mao, Mingsong Shi, Yonghong Fu, Xiaomin Jiang, Wen Feng, Youzhou He, Dingguo Xu, Lihua Yuan*New J. Chem., 2018, 42, 3857-3866.